The focus of the book was on stories about American soldiers or G.I.s. Initially, the stories involved Cold War adventures with strong anti-Communist themes, but over time the focus shifted to tales from World War II, and most of the stories after Quality ceased publishing the title were set during this period. As with other media, the World War II setting was sometimes used to discuss themes pertinent to contemporary conflicts such as the Vietnam War. The first issue of G.I. Combat was published in October 1952. When DC Comics acquired the rights to the Quality Comics characters and titles, they continued publishing the series starting with issue #44 (January 1957). G.I. Combat and Blackhawk were the only Quality titles which DC continued publishing. Many notable writers and artists worked on G.I. Combat during its run, including Robert Kanigher, who also edited the title, Joe Kubert, Jerry Grandenetti and Neal Adams.